Application process

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HOW TO APPLY?

Eligible interested candidates must complete the on-line Application Form by following the instructions below:

• Read the Call for Application and the Application Form carefully.
• Check the list of the supervisors and the Ph.D. programme specific topics and choose your research project.
• Fill the Application Form up.
• Prepare all the required documentation in PDF format and package it in a single zip file (max size 64 MB).
• Submit the zip file using submit application page.
• You will receive an acknowledgement message by email.

NOTE: double submission is allowed. In case of multiple submission successful applicants will be matched to the most suitable position according to MOGLYNET selection rules.

DEADLINE: November, 1st, 2015 23: 59pm

CEST - Central European Summer Time

Ph.D. Programme Projects and Group Leaders
Applicants to the MOGLYNET-EJD Programme are invited to select one or more of the following Projects and look it over with the prospective Group Leaders.

Position Nr.Supervisor 1Supervisor 2
1Matteo Zanda
m.zanda@abdn.ac.uk
University of Aberdeen		Alessandro Contini
alessandro.contini@unimi.it
University of Milano
Design, synthesis and evaluation of inhibitors of a specific glycolytic enzyme target relevant for atherosclerosis therapy having improved pharmacological properties and bioavailability.
Main Research Field: Chemistry
Sub Research Field: Biochemistry
Required Education Level: Master degree or equivalent in Chemistry, Medicinal Chemistry, Pharmacy
Main objectives are: design and synthesis of inhibitors of a specific glycolytic enzyme using a lead optimization process for selecting a compound with optimized potency, oral availability, metabolic stability, pharmacokinetics, and toxicology profile.
Secondments: i) six months at the University of Milano, to acquire skills on Hit-to-lead optimisation and acquisition of molecular modelling skills; ii) three months of industrial secondment at one of the industrial partner.
Position Nr.Supervisor 1Supervisor 2
2Stefano Bellosta
stefano.bellosta@unimi.it
University of Milano		Wim Martinet
wim.martinet@uantwerpen.be
University of Antwerpen
In vitro studies on the effects of modulators/inhibitors of a specific glycolytic enzyme relevant for atherosclerosis therapy on cultured cells and neovessels formation and in vivo studies.
Main Research Field: Pharmacological sciences
Required Education Level: Master Degree or equivalent in: Pharmacological sciences, Medical sciences, Biological sciences, Pharmacy
Main objectives are: i) evaluation of the effects of new modulators/inhibitors of a specific glycolytic enzyme in cultured smooth muscle cells, macrophages and ECs on different pro-atherogenic properties through different techniques (zymography; RT-PCR, western blot analysis, ELISA assay, immunocytochemistry); ii) in vivo studies on the effects of selected modulators identified in the in vitro experiments.

Secondments: i) six months at the University of Antwerp to acquire skills in setting-up in vivo pharmacological studies in a murine model of atherosclerosis to confirm the in vitro results. ii) three months of industrial secondment at one of the industrial partners.
Position Nr.Supervisor 1Supervisor 2
3Olga Tura
olgaturac@gmail.com
University of Barcelona		Paul Quax
p.h.a.quax@lumc.nl
University of Leiden
Selection of new modulators/inhibitors of a specific glycolytic enzyme relevant for atherosclerosis therapy by in vitro evaluation and in an animal model of atherosclerosis.
Main Research Field: Pharmacological, Sciences, Biological Sciences, Metabolomic, Mass spectrometry
Required Education Level: Master Degree or equivalent in: Pharmacological Sciences, Medical Sciences, Biological Sciences
Main objectives are: development of an in vitro model of endothelial pathology from patients undergoing treatment for acute myocardial infarction; characterization of central metabolism in control ECs; studies of the effects of glycolysis modulators on endothelial dysfunctionality; analysis of the modulators’ effects on in vitro angiogenesis models.
Secondments: i) six months at the University Leiden: Training on microsurgical interventions needed to construct the murine vein grafts and effects of glycolytic flux modulators on in vitro angiogenesis models. ii) three months of industrial secondment at one of the industrial partner.
Position Nr.Supervisor 1Supervisor 2
4Paul Quax
p.h.a.quax@lumc.nl
Univerisy of Leiden		Alberto Corsini
alberto.corsini@unimi.it
University of Milano
In vivo studies on the effects of inhibitors of a specific glycolytic enzyme relevant for atherosclerosis therapy on IP angiogenesis and on angiogenesis in vitro by following endothelial tube formation on matrigel.
Main Research Field: Biomedical Sciences
Required Education Level: Master Degree or equivalent in: Biomedical Sciences, Medical sciences, Biological sciences
Main objectives are: training in the microsurgical skills needed to perform mouse vein graft surgery and how to analyse intraplaque angiogenesis in atherosclerotic lesions; in vivo test the effects of modulators of a specific glycolytic enzyme on intraplaque angiogenesis and on vascular cells from a human and murine origin (cell proliferation, apoptosis, and activation status); in vitro angiogenesis using the matrigel tube formation assay and aortic ring assay and ADME profile (LC-MS) for determination of in vitro chemical and metabolic stability of inhibitors.
Secondments: i) six months at the University of Milano: training on ADME studies. ii) three months of industrial secondment at one of the industrial partner.
Position Nr.Supervisor 1Supervisor 2
5Paul Quax
p.h.a.quax@lumc.nl
Univerisy of Leiden		Mirela Delibegovic
m.delibegovic@abdn.ac.uk
University of Aberdeen
In vivo evaluation by optical and PET imaging of IP angiogenesis of atherosclerotic plaques, and validation of inhibitors of a specific glycolytic enzyme relevant for atherosclerosis therapy as fluorescent probes and PET tracers.
Main Research Field: Biomedical Sciences
Required Education Level: Master Degree or equivalent in: Biomedical Sciences, Medical sciences, Biological sciences
Main objectives are: training in the microsurgical skills needed to perform mouse vein graft surgery and analysis of intraplaque angiogenesis in atherosclerotic lesions; training in optical (NIRF) and PET imaging technologies for the detection of IP angiogenesis in atherosclerotic lesions in vivo test; validation of the efficacy of inhibitors on intraplaque angiogenesis in atherosclerotic lesions (optical and PET imaging technologies).
Secondments: i) six months at the University Aberdeen: training and use of imaging modalities for the detection of IP angiogenesis and in vivo monitoring of effects of inhibitors on IP angiogenesis in vein graft lesions ii) three months of industrial secondment at one of the industrial partner.
Position Nr.Supervisor 1Supervisor 2
6Wim Martinet
wim.martinet@uantwerpen.be
University of Antwerpen		Paul Quax
p.h.a.quax@lumc.nl
Univerisy of Leiden
In vivo studies on the effects of inhibitors of a selected specific glycolytic enzyme on atherosclerotic plaque composition and stability in a pre-clinical model and optical and morphometric image analysis.
Main Research Field: Pharmacological sciences
Required Education Level: Master Degree or equivalent in: Pharmacological sciences, Medical sciences, Biological sciences, Pharmacy
Main objectives are: in vivo pharmacological inhibition of IP angiogenesis in murine vein graft lesions in atherosclerosis a prone pre-clinical model as a rapid screening model using inhibitors; histological analysis of atherosclerotic lesions in a pre-clinical model; evaluation of the effects of selected inhibitors on plaque composition, stability, rupture and occurrence of myocardial infarctions, stroke and sudden death.
Secondments: i) six months at the University Leiden: Training in set-up of in vivo pharmacological studies, histology and optical morphometric image analysis. ii) three months of industrial secondment at one of the industrial partner.
Position Nr.Supervisor 1Supervisor 2
7Guido De Meyer
guido.demeyer@uantwerpen.be
University of Antwerpen		Mirela Delibegovic
m.delibegovic@abdn.ac.uk
University of Aberdeen
In vivo studies on the effects of selected specific glycolytic enzyme inhibitors on intraplaque angiogenesis and intraplaque haemorrhages in a pre-clinical model and in vivo PET imaging analysis.
Main Research Field: Pharmacological sciences
Required Education Level: Master Degree or equivalent in: Pharmacological sciences, Medical sciences, Biological sciences, Pharmacy
Main objectives are: training in set-up of in vivo pharmacological studies; histology and measurement of intraplaque angiogenesis and haemorrhages in atherosclerotic lesions of a pre-clinical model; evaluation of the effects of selected inhibitors on intraplaque angiogenesis and haemorrhages in atherosclerotic lesions of a pre-clinical model; training in in vivo molecular imaging and pre-clinical PET/CT imaging studies on a pre-clinical model.
Secondments: i) six months at the University Aberdeen: to define inhibition of intraplaque angiogenesis in atherosclerotic lesions in a pre-clinical model by selected inhibitors. ii) three months of industrial secondment at one of the industrial partner.
Position Nr.Supervisor 1Supervisor 2
8Matteo Zanda
m.zanda@abdn.ac.uk
University of Aberdeen		Guido De Meyer
guido.demeyer@uantwerpen.be
University of Antwerpen
Design, synthesis, radiosynthesis and in vivo PET Imaging of atherosclerotic plaque with of selected inhibitors of a specific glycolytic enzyme.
Main Research Field: Chemistry
Sub Research Field: Organic Chemistry
Required Education Level: Master degree or equivalent in Chemistry, Medicinal Chemistry, Pharmacy
Main objectives are: design and synthesis of fluorinated and fluorescent inhibitors as candidate cold PET tracers or optical imaging probes for in vivo detection of atherosclerotic plaque; radiosynthesis of selected inhibitors in “hot” form; PET/CT imaging studies of radiofluorinated compounds for determining the in vivo distribution of the tracers in pre-clinical models (PET/CT studies using 18F-inhybitor/s, and 18F-NaF).
Secondments: i) six months at the University Antwerp: development of preclinical model for in vivo PET Imaging. ii) three months of industrial secondment at one of the industrial partner.
Position Nr.Supervisor 1Supervisor 2
9Alessandro Contini
alessandro.contini@unimi.it
University of Milano		Joan Albert Barberà
JBARBERA@clinic.ub.es
University of Barcelona
Computational analysis of a specific glycolytic enzyme relevant for atherosclerosis therapy, design of peptide modulators and in vitro test.
Main Research Field: Chemistry
Sub Research Field: Computational Chemistry, Mass spectrometry
Required Education Level: Master Degree or equivalent: Chemistry, Medicinal Chemistry
Main objectives are: structural and functional analysis of a specific glycolytic enzyme by MD simulations; in silico design of peptides/peptidomimetics by MD and MM-PBSA/GBSA calculations; in vitro biological evaluation of designed glycolytic enzyme modulators on ECs
Secondments: i) six months at the University Barcelona: Training on in vitro biological evaluation of compounds modulator of a glycolytic enzyme. ii) four months of industrial secondment at one of the industrial partner.
Position Nr.Supervisor 1Supervisor 2
10Maria Luisa Gelmi
marialuisa.gelmi@unimi.it
University of Milano		Matteo Zanda
m.zanda@abdn.ac.uk
University of Aberdeen
Synthesis and structural characterization of peptide and peptidomimetics as modulators of a specific glycolytic enzyme relevant for atherosclerosis therapy.
Main Research Field: Chemistry
Sub Research Field: Organic Chemistry
Required Education Level: Master Degree or equivalent: Chemistry, Medicinal Chemistry
Main objectives are: chemical synthesis of peptides and peptidomimetics; conformational analysis of peptide/peptidomimetics (CD, FT-IR and NMR techniques); interaction studies with recombinant enzymes [CD, NMR spectroscopy (DOSY experiments), HR-MS and AFM].
Secondments: i) six months at the University of Aberdeen, to acquire skills on 18F-labeling of small molecules and/or peptides using radiofluorination and prosthetic group radiochemistry; ii) three months of industrial secondment at one of the industrial partner.
Position Nr.Supervisor 1Supervisor 2
11Marta Cascante
martacascante@ub.edu
University of Barcelona		Marina Carini
marina.carini@unimi.it
University of Milano
Studies of the role of inhibitors/modulators of a specific glycolytic enzyme relevant for atherosclerosis therapy in endothelial dysfunctionality associated to thromboembolic pulmonary disease.
Main Research Field: Pharmacological, Biological Sciences, Metabolomic, Mass Spectrometry
Required Education Level: Master Degree or equivalent in: Pharmacological Sciences, Medical Sciences, Biological Sciences, Pharmacy
Main objectives are: development of an in vitro model of endothelial pathology [preparation and characterization of patient derived endothelial cells (ECs) and their evaluation (morphology, antigen expression, proliferation, cellular aging and angiogenic potential)]; characterization of metabolic and proteomic profiles in control and pathologic ECs; effects of glycolysis modulation by modulators on ECs dysfunctionality.
Secondments: i) six months at the University of Milano: Training on quantitative proteomics. A large-scale identification of protein expression in normal and pathological ECs. ii) three months of industrial secondment at one of the industrial partner.
Position Nr.Supervisor 1Supervisor 2
12Marina Carini
marina.carini@unimi.it
University of Milano		Marta Cascante
martacascante@ub.edu
University of Barcelona
Bioanalytical and proteomic approaches in the study of pathologic ECs dysfunctionality, oxidative stress and the effects of modulators of a specific glycolitic enzyme relevant for atherosclerosis therapy.
Main Research Field: Chemistry, Pharmacological sciences, Mass spectrometry, Proteomics
Sub Research Field: Analytical chemistry, Applied chemistry, Biochemistry
Required Education Level: Master Degree or equivalent: Chemistry, Pharmacological sciences, Biological sciences, Pharmacy
Research project 12: bioanalytical and proteomic approaches in the study of pathologic endothelial cells (ECs) dysfunctionality, oxidative stress and the effects of modulators of a specific glycolitic enzyme. Main objectives: metabolic dysfunction studies and protein expression modulation in pathologic ECs (metabolic and lipidomic profiles, quantitative proteomics by mass spectrometry); studies on protein expression/modulation by inhibitiors; role of oxidative stress/redox status in pathologic ECs and effects of modulators in ECs dysfunctionality.
Secondments: i) six months at the University Barcelona: Training on metabolic and lipidomic profile of pathologic ECs. ii) three months of industrial secondment at one of the industrial partner.

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