Research themes

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MOGLYNET-EJD programme would like to stress the attention on the following research fields:

• Modulation of glycolytic enzymes activity as a therapeutic strategy to control atherogenesis and plaque rupture;
• Development of new activators of specific glycolytic enzymes activity as a new strategy to control atherogenesis;
• Studies on the role of glycolytic enzyme modulators and other glycolytic pathway flux key players in endothelial dysfunctionality associated to comorbidities in patients with atherosclerosis;

The research methodology and approach proposed by the MOGLYNET consortium is strongly multidisciplinary and will involve a number of different state-of-the-art technologies and methodologies relevant to the project:

• Computational chemistry
• Chemical synthesis
• Bioanalytics and biophysics
• In vitro biological evaluation
• In vivo pre-clinical studies
• Molecular imaging
• Metabolomics
• Proteomics
• Oxidative stress

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